The Messiah would be born of the "seed" of a woman.
OT Prophecy NT Fulfillment
Genesis 3:15a
"And I will put enmity between thee and the woman, and between thy seed and her seed; it shall bruise thy head, and thou shalt bruise his heel."
Luke 1:34-35
[34] "Then said Mary unto the angel, How shall this be, seeing I know not a man?
[35] And the angel answered and said unto her, The Holy Ghost shall come upon thee, and the power of the Highest shall overshadow thee: therefore also that holy thing which shall be born of thee shall be called the Son of God."
Tanakh - Bereshit - Genesis 3:15a
"And I will put enmity between thee and the woman, and between thy seed and her seed; they shall bruise thy head, and thou shalt bruise their heel."
Hebrew OT - Genesis 3:15a
הַעֲרָה נִיתֵּן בֵּין זַרְעֲךָ וּבֵין זַרְעָהּ
הוּא יְשׁוּפְךָ רֹאשׁ וְאַתָּה תְּשׁוּפֶנּוּ עָקֵב